Simulating Nature Today for a More Resilient Tomorrow
What Are Ecotrons?
Ecotrons are state-of-the-art labs that recreate ecosystems - like forests, grasslands, or marine habitats. They can range in size between a few square meters to an acre or more. Think of them as high-tech greenhouses that allow controlled, reproducible study of environmental problems and potential solutions. These ecosystem models are loaded with sensors, and biological samples can be taken periodically for DNA sequencing and other molecular testing. This constant flow of information from a multitude of ecotrons can be analyzed using AI to find "hot spots" in the data that indicate statistically significant differences between highly controlled conditions. This emerging field of science might best be described as Comparative Biospheromics.
Why Ecotrons Matter
Synthetic biology involves manipulating DNA to create new biological components, devices, and systems, or to modify organisms for specific purposes. There is currently much apprehension about whether such technology will be safe or effective.
On an ethical level, some think we have no business tinkering with the fundamental molecule of life. Others are eager to see a bioeconomy blossom. Ecotrons can help ensure we innovate responsibly, with rigorous science to guide us.
Protecting Earth: They can help us test biological agents that clean pollution and control pests. They can allow us to test genetically modified food crops that can be grown more organically and affordably. They can help us understand and respond to higher carbon dioxide levels in more meaningful ways.
Resolving Debates: By testing biotechnologies like genetically engineered organisms or chimeric DNA in a controlled and reproducible way, ecotrons can provide transparent data to address concerns about safety and ethics.
Exploring Space: Ecotrons can also lend insight into how to bottle a biosphere so people can one day live and work off-planet.
Support Ecotron Research
Synthetic biology will require far more public support for applications to be fully realized outside of laboratories. Without funding and public trust, we risk losing tools to tackle environmental problems, ensure safe biotechnologies, and advance space exploration.
Learn about our vision to fund and scale ecotron facilities through a collaborative endowment:
Comparative Biospheromics
A 3-Tier Investment & Partnership Prospectus with Endowment Fund
Overview
Comparative Biospheromics is a new field at the intersection of ecological genomics, synthetic biology, and systems engineering. Its goal is to evaluate the ecological behavior and biosafety of engineered organisms in complex, semi-natural testbed environments called ecotrons. This prospectus outlines a three-tier plan to fund and scale a world-class testing ecosystem based in Tucson, Arizona, leveraging the University of Arizona's land, talent, and position in the heart of one of the most biosafety-conducive landscapes on Earth.
A key component of this vision is the establishment of a $500M–$1B endowment fund, created by pooling contributions from multiple private foundations. The revenues from this endowment will sustain the scientific infrastructure, including ecotron facilities, laboratories, and data systems, while attracting top researchers who bring their own grant funding, further amplifying the project's impact.
This prospectus outlines a vision for collaboration. It is shared here in the hope of finding institutional and individual partners to develop this idea further. This proposal is independent of any current institutional endorsement and does not represent any official position of the University of Arizona. The Comparative Biospheromics Network welcomes ideas and collaborators committed to safe and forward-looking synthetic biology research.
Why the Sonoran Desert?
Natural Containment: The Sonoran Desert minimizes host uptake in the event of a leak.
Academic Alignment: The University of Arizona is a national leader in environmental and synthetic biology research.
Available Land: Hundreds of acres, allowing ample space for modular infrastructure and future expansion.
Climate: Low humidity and minimal vegetation create an ideal setting for controlled release studies.
Tier 1: Launch & Prototype ($500K – $2M)
Spin out a service-oriented organizational arm.
Develop early branding, partner outreach, and ops infrastructure.
Hire 2–3 key people (biz dev, science/tech lead, program coordinator).
Build 1–2 prototype ecotrons for demonstration and early testing.
Tier 2: Scientific Validation & Data Sharing Platform ($5M)
Construct a 24-ecotron array designed for comparative testing across ecosystems.
Publish data to support research, standards development, and educational use.
Begin hosting university partners and early commercial tests.
Link into NSF, USDA, DOE, and international research funding streams.
Develop a 100-acre zone of testbed arrays at multiple scales (micro to field trial).
Maintain strict biosafety protocols, digital twin data pipelines, and automated monitoring.
Support global product testing: researchers and startups send engineered biology for performance/biosafety evaluation.
Generate high-resolution ecological genomics data for industry, science, and regulatory collaboration.
Leverage endowment revenues to sustain infrastructure and attract researchers with external funding.
Funding Strategy
Endowment Fund: Pool contributions from private foundations (e.g., Gates Foundation, Wellcome Trust, Bezos Earth Fund) to create a $500M–$1B endowment. Annual revenues (estimated 4–5% or $20M–$50M/year) will fund facility operations, maintenance, and core staff.
Government: Approach NSF, DOE, USDA for ecotron infrastructure and early research grants.
Philanthropy: Engage additional foundations like Open Philanthropy, Moore, Sloan, and others to seed public-good science and underfunded research.
Venture Capital: Focus on product-specific spinouts (e.g., engineered plants, soil additives, bioremediation agents) to fund commercialization.
Researcher Grants: Attract top scientists who bring their own funding (e.g., NIH, NSF grants), leveraging the endowment-supported infrastructure.
Impact
Create a global hub for evaluating engineered biology before environmental release.
Protect ecosystems while accelerating synthetic biology innovation.
Generate public trust and scientific transparency in the age of bioengineering.
Position a non-profit institute in the Sonoran Desert as a world leader in biosafety and ecological performance science.
Sustain long-term research through endowment revenues and external grants.
Select your state below to personalize a letter to your senators and help champion ecotron science.
Subject: Support Ecotron Science
Dear [Senator’s Name],
I am writing to urge your support for ecotron science, a critical tool for solving environmental challenges while ensuring the safe and ethical use of synthetic biology. Ecotrons are controlled-environment labs that mimic real ecosystems — like forests, grasslands, and marine habitats — in a way that lets scientists study ecological problems and technical solutions with precision and safety.
Ecotrons can help us test biological agents that clean pollution and control pests. They can allow us to test genetically modified food crops that can be grown more organically and affordably. They can help us understand and respond to higher carbon dioxide levels. By testing applications of synthetic biology in a controlled way, ecotrons can provide transparent data to address concerns about safety and ethics. They can also lend insight into how to bottle a biosphere so people can one day live and work off-planet.
Some fear that altering DNA is playing God. In the same vein, God gave us the ability to engineer ecotrons and study biotechnologies in contained settings so we could increase biosafety, invent novel solutions, and build trust through open science.
Without public support, synthetic biology and ecotron science could lose funding or face bans, halting progress on environmental solutions and human space exploration. Ecotrons are our safeguard — a way to innovate responsibly while respecting ethical concerns.
Please champion federal funding and policies that support ecotron research facilities. Desert landscapes provide the highest level of containment, so a location isolated from waterways and plush vegetation would be optimal for biosafety. We will need a lot of ecotrons to achieve statistically significant reproducibility. Let us keep science moving forward for a healthier planet and a more resilient future.
Sincerely, [Your Name]
Copy the letter above and paste it into your senators’ contact forms.
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Support ecotron research to tackle environmental problems, ensure safe biotech, and advance space exploration. A letter for your senators is included! Learn more: https://aime2solve.github.io/EcotronScience #Ecotrons #ComparativeBiospheromics
Roy, J., Rineau, F., De Boeck, H. J., et al. (2021). Ecotrons: Powerful and versatile ecosystem analysers for ecology, agronomy and environmental science. Global Change Biology, 27(7), 1387-1407. https://doi.org/10.1111/gcb.15471
de Lorenzo, V. (2022). Environmental Galenics: large-scale fortification of extant microbiomes with engineered bioremediation agents. Philosophical Transactions of the Royal Society B: Biological Sciences, 377(1857), 20210395. https://doi.org/10.1098/rstb.2021.0395
Miklau, M., Burn, S. J., Eckerstorfer, M., et al. (2024). Horizon scanning of potential environmental applications of terrestrial animals, fish, algae and microorganisms produced by genetic modification, including the use of new genomic techniques. Frontiers in Genome Editing, 6, 1376927. Published 2024 Jun 13. https://doi.org/10.3389/fgeed.2024.1376927
Patrick, S. & Barton, J. (2024). Mitigating Risks of Gene Editing and Synthetic Biology: Global Governance Priorities. CEIP: Carnegie Endowment for International Peace. United States of America. Retrieved from https://coilink.org/20.500.12592/6ba5fug on 17 May 2025. COI: 20.500.12592/6ba5fug